So after failing at the TBR challenge in 2009. In 2010 I'm going to take part in the DIK reading challenge. Details on DIK here. Basically you have the choice of the 188 books on the DIK island. There is an incredibly wide range from the classics, to romance, to sci-fi, so should definitely be something there to interest me every month.
Also as Nicole suggested I'm going to try and read 52 books in 52 weeks. Which should make a little dent (at least) in my TBR pile.
Edited to Add - I've also joined the m/m reading challenge for 2010. Aiming to read 20+ stories. (If anyone knows how to make the button in my sidebar completely viewable please let me know. I suck at the tech stuff.)